Research

Dr. Robert P. Schleimer, Division Chief of Allergy Immunology

Research efforts in the Northwestern Sinus and Allergy Center are led by Robert P. Schleimer, PhD in association with Atsushi Kato, PhD and Katie Hulse, PhD. Dr. Schleimer is also the head of the Division of Allergy and Immunology at Northwestern University Feinberg School of Medicine. Dr. Bruce Tan leads the clinical research activities. Caroline Price serves as the research coordinator for the Sinus and Allergy Center.

Dr. Schleimer’s Bio

Dr. Kato’s Bio

Dr. Tan’s Bio

Dr. Hulse’s Bio

 

Clinical Research Studies

We have several research studies that are currently enrolling patients. If you are already a patient at Northwestern Medical Group and you are interested in participating, please ask your doctor during your clinic appointment. If you are not a Northwestern patient but are interested, there are several opportunities to participate in an ongoing clinical study for sinus and allergy research. Find out more at ClinicalTrials.gov

 

Studies Currently Enrolling Patients

  1. Chronic Rhinosinusitis (CRS) Registry
  2. Aspirin Exacerbated Respiratory Disease (AERD) Study
  3. Anti-Inflammatory Agent in Sinusitis (E1416)
  4. Benralizumab (OSTRO) in CRSwNP

Completed Studies 

  1. Improving Symptom-Based Diagnosis of Chronic Sinusitis (CRS)
  2. Patient Knowledge and Perception of Sinus CT Scan
  3. RESOLVE – Steroid-Releasing S8 Sinus Implant
  4. Steroid Therapy Before Surgery in Patients with Chronic Sinusitis (CRS) With Nasal Polyps
  5. Laryngopharyngeal Reflux (LPR) pH Probe
  6. OptiNose
  7. MERLOT – Medical Therapy Versus Balloon Sinus Dilation for Patients with Chronic Rhinosinusitis
  8. Short-Term Steroid Therapy in Patients with Chronic Sinusitis (CRS) Without Nasal Polyps
  9. RESOLVE II – Steroid-Releasing S8 Sinus Implant
  10. Allakos- AK-001 Phase II Randomized Control Trial

 

Ongoing Sponsored Research Projects

R01         AI134952  NIH/NIAID

AUTOANTIBODY MEDIATED PATHOGENESIS IN CHRONIC RHINOSINUSITIS WITH NASAL POLYPS: MECHANISMS AND CONSEQUENCES              TAN, BRUCE K    NORTHWESTERN UNIVERSITY AT CHICAGO

R01         DC016645 NIH/NIAID

TYPE-2 INFLAMMATION MEDIATES OLFACTORY LOSS IN CHRONIC RHINOSINUSITIS: MECHANISMS AND THERAPEUTIC OPPORTUNITIES  TAN, BRUCE K    NORTHWESTERN UNIVERSITY AT CHICAGO

2 R01 HL68546-24 NIH/NHLBI
Glucocorticoid Action in Inflammatory Disease.
To assess the mechanisms of glucocorticoid actions in allergic disease and experimental antigen challenges.

1 R01 HL078860-01A1 NIH/NHLBI
Role of Epithelium in Immunity, Inflammation and Disease.
The goal of this study is to assess what role epithelial cells play in innate immune responses, adaptive immune regulation and inflammation in chronic rhinosinusitis.

0985-370-F281 Northwestern Memorial Foundation
Novel Plant-Human Fusion Proteins for the Purpose of Blocking Peanut Induced Allergy.
The goal is to engineer constructs and express plant-human fusion proteins that will inhibit peanut-induced allergic reactions
in humans.

1R01AI072570-01 NIH/NHLBI
Epithelial BAFF and APRIL in Airway Inflammation, Immunity and Disease.
The purpose of this grant is to determine the importance of BAFF in inflammatory diseases of the airways in human subjects and using a mouse model.

1K23DC012067 NIH/NIDCD & Supplemental Career Scientist Award from the Triological Society / American College of Surgeons
The Role for B-cell mediated Olfactory Loss in Chronic Sinusitis with Nasal Polyps
The goal of this study is to examine the effects of B-cell mediated inflammation in the olfactory loss associated with chronic rhinosinusitis with nasal polyps.

 

FOOD SUPPLEMENTS

Bruce Tan earns two R01 grants!

 

Dr. Whitney Stevens Awarded Parker B. Francis Grant

Northwestern Allergy and Sinus Center is very proud of Dr. Whitney Stevens who recently was granted the very coveted Parker B. Francis Fellowship in Pulmonary Research. The prestigious fellowship “is intended to support the development of outstanding investigators embarking on careers in pulmonary, critical care and sleep medicine.” Dr. Stevens’ research focuses on the study of Aspirin Exacerbated Respiratory Disease or Samter’s Triad.

Dr. Schleimer Wins the Tripartite Prize

Congratulations to our very own Dr. Robert P. Schleimer who was awarded the prestigious Tripartite Legacy Faculty Prize in Translational Science and Education. Dr. Schleimer received the honor on the 11th Annual Lewis Landsberg Research Day on April 2nd, 2015.

Sinus And Allergy Center Awarded NIH Program Grant

The Sinus and Allergy Center is honored to have received notice that it has been awarded a major NIH-supported program project grant to fund a collaborative effort between Northwestern University, The University of Chicago, the Geisinger Health System and the Johns Hopkins Bloomberg School of Public Health to study the epidemiology, genetics and pathobiology of chronic rhinosinusitis. The collaborative group, collectively known as the Chronic Rhinosinusitis Integrative Studies Program (CRISP) is the only program project grant (P01) recipient in the United States studying this common but poorly understood disease. Program project grants are more complex in scope and budget than individual research grants. While individual research grants are awarded to support the work of one principal investigator who, with supporting staff, is addressing a scientific problem, program project grants are available to a group of several investigators with differing areas of expertise who wish to collaborate in research by pooling their talents and resources. These resources will fund continued studies examining the genetic, environmental, molecular and immunologic underpinnings of chronic rhinosinusitis in order to discover new means of treating this disease.

Dr. Bruce Tan has been awarded the 2012 Triological Society/American College of Surgeons Career Scientist Award Grant

This grant will supplement his investigations in the role of autoimmunity in Chronic Rhinosinusitis. The Triological Society is the most established society in the Otolaryngology specialty and promotes research into the causes of and treatments for diseases of the Ear, Nose and Throat.  The American College of Surgeons is a scientific and educational association of surgeons that was founded in 1913 to improve the quality of care for the surgical patient by setting high standards for surgical education and practice.

Dr. Bruce Tan has been awarded the 2011 Triological Society Career Development Award Grant 

Dr. Tan is investigating the role of autoimmunity in Chronic Rhinosinusitis. The Triological Society is the most established society in the Otolaryngology specialty and promotes research into the causes of and treatments for diseases of the Ear, Nose and Throat

Dr. Bruce Tan has been awarded an NIH K23 Mentored Patient-Oriented Research Career Development Award

This Award is aimed to study “The Role of B-cell mediated Olfactory Loss in Chronic Sinusitis with Nasal Polyps.”

Selected Publications 

Thompson CF, Price CP, Huang JH, Min JY, Suh LA, Shintani-Smith S, Conley DB, Schleimer RP, Kern RC, Tan BK. A pilot study of symptom profiles from a polyp vs an eosinophilic-based classification of chronic rhinosinusitis. Thompson Int Forum Allergy Rhinol. 2015 Dec 18. doi: 10.1002/alr.21687. [Epub ahead of print]PMID: 26683389 [PubMed – as supplied by publisher]

Kern RC. EDITORIAL. Int Forum Allergy Rhinol. 2016 Jan;6(1):5-7. doi: 10.1002/alr.21713. No abstract available. PMID: 26749201 [PubMed – in process]

Daramola OO, Kern RC.An update regarding the treatment of nonallergic rhinitis.Curr Opin Otolaryngol Head Neck Surg. 2016 Feb;24(1):10-4. doi: 10.1097/MOO.0000000000000225. PMID: 26731682 [PubMed – in process]

Heymann HB, Thompson CF, Lissner GS, Kern RC. Nasoorbital Osteoma Presenting as Valsalva-Induced Orbital Emphysema. Ophthal Plast Reconstr Surg. 2015 Dec 14. [Epub ahead of print] PMID: 26669293 [PubMed – as supplied by publisher]

Stevens WW, Lee RJ, Schleimer RP, Cohen NA. Chronic rhinosinusitis pathogenesis. J Allergy Clin Immunol. 2015 Dec;136(6):1442-53. doi: 10.1016/j.jaci.2015.10.009. Review. PMID: 26654193 [PubMed – in process]

Rudmik L, Hopkins C, Peters A, Smith TL, Schlosser RJ, Soler ZM. Patient-reported outcome measures for adult chronic rhinosinusitis: A systematic review and quality assessment. J Allergy Clin Immunol. 2015 Dec;136(6):1532-1540.e2. doi: 10.1016/j.jaci.2015.10.012. PMID: 26654198 [PubMed – in process]

Vieira BL, Hernandez DJ, Qin C, Smith SS, Kim JY, Dutra JC. The impact of resident involvement on otolaryngology surgical outcomes. Laryngoscope. 2016 Mar;126(3):602-7. doi: 10.1002/lary.25046. Epub 2015 Nov 3. PMID: 26526707 [PubMed – in process]

Cramer JD, Kern RC, Tan BK, Peters AT, Evans CT, Smith SS. Laryngoscope. Potential national savings from prescribing guideline-recommended antibiotics for acute rhinosinusitis. 2016 Mar;126(3):579-81. doi: 10.1002/lary.25719. Epub 2015 Oct 28. No abstract available.  PMID: 26509838 [PubMed – in process]

Cho SH, Kim DW, Lee SH, Kolliputi N, Hong SJ, Suh L, Norton J, Hulse KE, Seshadri S, Conley DB, Kern RC, Tan BK, Peters A, Grammer LC, Schleimer RP. Age-Related Increased Prevalence of Asthma and Nasal Polyps in Chronic Rhinosinusitis and Its Association with Altered IL-6 Trans-Signaling. Am J Respir Cell Mol Biol. 2015 Nov;53(5):601-6. doi: 10.1165/rcmb.2015-0207RC. PubMed PMID: 26266960.

Ference EH, Tan BK, Hulse KE, Chandra RK, Smith SB, Kern RC, Conley DB, Smith SS. Commentary on gender differences in prevalence, treatment, and quality of life of patients with chronic rhinosinusitis. Allergy Rhinol (Providence). 2015 Jan;6(2):82-8. doi: 10.2500/ar.2015.6.0120. PubMed PMID: 26302727; PubMed Central PMCID: PMC4541639.

Hirsch AG, Yan XS, Sundaresan AS, Tan BK, Schleimer RP, Kern RC, Kennedy TL, Greene JS, Schwartz BS. Five-year risk of incident disease following a diagnosis of chronic rhinosinusitis. Allergy. 2015 Aug 31. doi: 10.1111/all.12759. [Epub ahead of print] PubMed PMID: 26332371.

Chandra RK, Kern RC, Cutler JL, Welch KC, Russell PT. REMODEL larger cohort with long-term outcomes and meta-analysis of standalone balloon dilation studies. Laryngoscope. 2015 Jul 30. doi: 10.1002/lary.25507. [Epub ahead of print] PubMed PMID: 26228589.

Seshadri S, Lu X, Purkey MR, Homma T, Choi AW, Carter R, Suh L, Norton J, Harris KE, Conley DB, Kato A, Avila PC, Czarnocka B, Kopp PA, Peters AT, Grammer LC, Chandra RK, Tan BK, Liu Z, Kern RC, Schleimer RP. Increased expression of the epithelial anion transporter pendrin/SLC26A4 in nasal polyps of patients with chronic rhinosinusitis. J Allergy Clin Immunol. 2015 Jul 1. pie: S0091-6749(15)00730-7. doi: 10.1016/j.jaci.2015.05.024. [Epub ahead of print] PubMed PMID: 26143180.

Welch KC. Neurologic Complications and Treatment. Otolaryngol Clin North Am. 2015 Oct;48(5):769-82. doi: 10.1016/j.otc.2015.05.005. Epub 2015 Jul 2. Review. PubMed PMID: 26143103.

Thompson CF, Kern RC, Conley DB. Olfaction in Endoscopic Sinus and Skull Base Surgery. Otolaryngol Clin North Am. 2015 Oct;48(5):795-804. dos: 10.1016/j.otc.2015.05.007. Epub 2015 Jun 24. Review. PubMed PMID: 26117298

Gouveia CJ, Qureshi HA, Kern RC, Shintani Smith S. National Institutes of Health Funding for Obstructive Sleep Apnea: An Opportunity for Otolaryngologists. Otolaryngol Head Neck Surg. 2015 Oct;153(4):671-8. doi: 10.1177/0194599815589584. Epub 2015 Jun 17. PubMed PMID: 26084829.

Sundaresan AS, Hirsch AG, Storm M, Tan BK, Kennedy TL, Greene JS, Kern RC, Schwartz BS. Occupational and environmental risk factors for chronic rhinosinusitis: a systematic review. Int Forum Allergy Rhinol. 2015 Jun 16. doi: 10.1002/alr.21573. [Epub ahead of print] PubMed PMID: 26077513.

Ference EH, Stubbs V, Lidder AK, Chandra RK, Conley D, Avila PC, Hirsch AG, Min JY, Shintani Smith S, Kern RC, Tan BK. Measurement and comparison of health utility assessments in chronic rhinosinusitis. Int Forum Allergy Rhinol. 2015 Oct;5(10):929-36. doi: 10.1002/alr.21556. Epub 2015 Jun 16. PubMed PMID: 26077390; PubMed Central PMCID: PMC4607564.

Stevens WW, Ocampo CJ, Berdnikovs S, Sakashita M, Mahdavinia M, Suh L, Takabayashi T, Norton JE, Hulse KE, Conley DB, Chandra RK, Tan BK, Peters AT, Grammer LC 3rd, Kato A, Harris KE, Carter RG, Fujieda S, Kern RC, Schleimer RP. Cytokines in Chronic Rhinosinusitis. Role in Eosinophilia and Aspirin-exacerbated Respiratory Disease. Am J Respir Crit Care Med. 2015 Sep 15;192(6):682-94. doi: 10.1164/rccm.201412-2278OC. PubMed PMID: 26067893; PubMed Central PMCID: PMC4595675.

Lobo BC, Ting JY, Tan BK. Cost efficient workup and management of patients with chronic rhinosinusitis – challenges and unmet needs. Curr Otorhinolaryngol Rep. 2015 Jun;3(2):94-100. PubMed PMID: 26029489; PubMed Central PMCID: PMC4443922.

Ference EH, Smith SS, Conley D, Chandra RK. Surgical anatomy and variations of the infraorbital nerve. Laryngoscope. 2015 Jun;125(6):1296-300. doi: 10.1002/lary.25089. Epub 2015 Jan 13. PubMed PMID: 25992806.

Stevens WW, Peters AT, Suh L, Norton JE, Kern RC, Conley DB, Chandra RK, Tan BK, Grammer LC, Harris KE, Carter RG, Kato A, Urbanek M, Schleimer RP, Hulse KE. A retrospective, cross-sectional study reveals that women with CRSwNP have more severe disease than men. Immun Inflamm Dis. 2015 Mar;3(1):14-22. doi: 10.1002/iid3.46. Epub 2015 Feb 12. PubMed PMID: 25866636; PubMed Central PMCID: PMC4386911.

Lam K, Schleimer R, Kern RC. The Etiology and Pathogenesis of Chronic Rhinosinusitis: a Review of Current Hypotheses. Curr Allergy Asthma Rep. 2015 Jul;15(7):41. doi: 10.1007/s11882-015-0540-2. Review. PubMed PMID: 26143392.

Pothoven KL, Norton JE, Hulse KE, Suh LA, Carter RG, Rocci E, Harris KE, Shintani-Smith S, Conley DB, Chandra RK, Liu MC, Kato A, Gonsalves N, Grammer LC 3rd, Peters AT, Kern RC, Bryce PJ, Tan BK, Schleimer RP. Oncostatin M promotes mucosal epithelial barrier dysfunction, and its expression is increased in patients with eosinophilic mucosal disease. J Allergy Clin Immunol. 2015 Sep;136(3):737-746.e4. doi: 10.1016/j.jaci.2015.01.043. Epub 2015 Apr 1. PubMed PMID: 25840724; PubMed Central PMCID: PMC4562861.

Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, Brook I, Kumar KA, Kramper M, Orlandi RR, Palmer JN, Patel ZM, Peters A, Walsh SA, Corrigan MD. Clinical practice guideline (update): Adult Sinusitis Executive Summary. Otolaryngol Head Neck Surg. 2015 Apr;152(4):598-609. doi: 10.1177/0194599815574247. PubMed PMID: 25833927.

Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, Brook I, Ashok Kumar K, Kramper M, Orlandi RR, Palmer JN, Patel ZM, Peters A, Walsh SA, Corrigan MD. Clinical practice guideline (update): adult sinusitis. Otolaryngol Head Neck Surg. 2015 Apr;152(2 Suppl):S1-S39. doi: 10.1177/0194599815572097. PubMed PMID: 25832968.

Kern RC. Historical classics: Editorial. Laryngoscope. 2015 Apr;125(4):773. doi: 10.1002/lary.25216. Epub 2015 Mar 14. PubMed PMID: 25773495.

Mahdavinia M, Hsu J, Norton JE, Carter RG, Simon P, Siebert J, Cheatem L, Suh LA, Peters AT, Grammer LC 3rd, Kato A, Tan BK, Conley DB, Avila PC, Kern RC, Pinto JM, Schleimer RP. Association of common filaggrin null mutations with atopy but not chronic rhinosinusitis. Ann Allergy Asthma Immunol. 2015 May;114(5):420-1. doi: 10.1016/j.anai.2015.01.019. Epub 2015 Mar 4. PubMed PMID: 25747786; PubMed Central PMCID: PMC4426019.

Gawron AJ, Feinglass J, Pandolfino JE, Tan BK, Bove MJ, Shintani-Smith S. Brand name and generic proton pump inhibitor prescriptions in the United States: insights from the national ambulatory medical care survey (2006-2010). Gastroenterol Res Pract. 2015;2015:689531. doi: 10.1155/2015/689531. Pub 2015 Feb 5. PubMed PMID: 25733976; PubMed Central PMCID: PMC4334865.

Schoepfer AM, Panczak R, Zwahlen M, Kuehni CE, Coslovsky M, Maurer E, Haas NA, Alexander JA, Dellon ES, Gonsalves N, Hirano I, Leung J, Bussmann C, Collins MH, Newbury RO, De Petris G, Smyrk TC, Woosley JT, Yan P, Yang GY, Romero Y, Katzka DA, Furuta GT, Gupta SK, Aceves SS, Chehade M, Blanchard C, Straumann A, Safroneeva E; International EEsAI Study Group. How do gastroenterologists assess overall activity of eosinophilic esophagitis in adult patients? Am J Gastroenterol. 2015 Mar;110(3):402-14. doi: 10.1038/ajg.2015.32. Epub 2015 Mar 3. PubMed PMID: 25732414.

Qureshi H, Ference E, Novis S, Pritchett CV, Smith SS, Schroeder JW. Trends in the management of pediatric peritonsillar abscess infections in the U.S., 2000-2009. Int J Pediatr Otorhinolaryngol. 2015 Apr;79(4):527-31. doi: 10.1016/j.ijporl.2015.01.021. Epub 2015 Jan 28. PubMed PMID: 25708703.

Kashani S, Carr TF, Grammer LC, Schleimer RP, Hulse KE, Kato A, Kern RC, Conley DB, Chandra RK, Tan BK, Peters AT. Clinical characteristics of adults with chronic rhinosinusitis and specific antibody deficiency. J Allergy Clin Immunol Pract. 2015 Mar-Apr;3(2):236-42. doi: 10.1016/j.jaip.2014.09.022. Epub 2014 Nov 25. PubMed PMID: 25609325; PubMed Central PMCID: PMC4391952.

Qureshi HA, Ference EH, Tan BK, Chandra RK, Kern RC, Smith SS. National trends in retropharyngeal abscess among adult inpatients with peritonsillar abscess. Otolaryngol Head Neck Surg. 2015 Apr;152(4):661-6. doi: 10.1177/0194599814568286. Epub 2015 Jan 20. PubMed PMID: 25605696.

Thompson CF, Conley DB. What is the optimal maxillary antrostomy size during sinus surgery? Curr Opin Otolaryngol Head Neck Surg. 2015 Feb;23(1):34-8. doi: 10.1097/MOO.0000000000000128. Review. PubMed PMID: 25502601.

Min JY, Tan BK. Risk factors for chronic rhinosinusitis. Curr Opin Allergy Clin Immunol. 2015 Feb;15(1):1-13. doi: 10.1097/ACI.0000000000000128. Review. PubMed PMID: 25479315; PubMed Central PMCID: PMC4368058.

Bhushan B, Homma T, Norton JE, Sha Q, Siebert J, Gupta DS, Schroeder JW Jr, Schleimer RP. Suppression of epithelial signal transducer and activator of transcription 1 activation by extracts of Aspergillus fumigatus. Am J Respir Cell Mol Biol. 2015 Jul;53(1):87-95. doi: 10.1165/rcmb.2014-0333OC. PubMed PMID: 25474274; PubMed Central PMCID: PMC4566112.

Bachert C, Pawankar R, Zhang L, Bunnag C, Fokkens WJ, Hamilos DL, Jirapongsananuruk O, Kern R, Meltzer EO, Mullol J, Naclerio R, Pilan R, Rhee CS, Suzaki H, Voegels R, Blaiss M. ICON: chronic rhinosinusitis. World Allergy Organ J. 2014 Oct 27;7(1):25. doi: 10.1186/1939-4551-7-25. eCollection 2014. PubMed PMID: 25379119; PubMed Central PMCID: PMC4213581.

Daramola OO, Lidder AK, Ramli R, Chandra RK, Shintani-Smith S, Conley DB, Kern RC, Tan BK. Patient knowledge and perception of computed tomography scan in the management of chronic rhinosinusitis symptoms. Laryngoscope. 2015 Apr;125(4):791-5. doi: 10.1002/lary.24992. Epub 2014 Oct 24. PubMed PMID: 25346013; PubMed Central PMCID: PMC4376556.

Mahdavinia M, Suh LA, Carter RG, Stevens WW, Norton JE, Kato A, Tan BK, Kern RC, Conley DB, Chandra R, Lavin J, Peters AT, Grammer LC 3rd, Schleimer RP. Increased noneosinophilic nasal polyps in chronic rhinosinusitis in US second-generation Asians suggest genetic regulation of eosinophilia. J Allergy Clin Immunol. 2015 Feb;135(2):576-9. doi: 10.1016/j.jaci.2014.08.031. EPub 2014 Oct 11. PubMed PMID: 25312761; PubMed Central PMCID: PMC4323954.

Lam K, Conley DB, Liu K, Kern RC, Tan BK, Richter CP. Effect of ionic compositions in nasal irrigations on human olfactory thresholds. Laryngoscope. 2015 Feb;125(2):E50-6. doi: 10.1002/lary.24941. Epub 2014 Sep 30. PubMed PMID: 25267347.

Ference EH, Graber M, Conley D, Chandra RK, Tan BK, Evans C, Pynnonen M, Smith SS. Operative utilization of balloon versus traditional endoscopic sinus surgery. Laryngoscope. 2015 Jan;125(1):49-56. doi: 10.1002/lary.24901. Epub 2014 Sep 2. PubMed PMID: 25180840; PubMed Central PMCID: PMC4349682.

Ference EH, Schroeder JW Jr, Qureshi H, Conley D, Chandra RK, Tan BK, Shintani Smith S. Current utilization of balloon dilation versus endoscopic techniques in pediatric sinus surgery. Otolaryngol Head Neck Surg. 2014 Nov;151(5):852-60. doi: 10.1177/0194599814545442. Epub 2014 Aug 4. Erratum in: Otolaryngol Head Neck Surg. 2015 Aug;153(2):310-1. PubMed PMID: 25091194.

Stevens WW, Schleimer RP, Chandra RK, Peters AT. Biology of nasal polyposis. J Allergy Clin Immunol. 2014 May;133(5):1503, 1503.e1-4. doi: 10.1016/j.jaci.2014.03.022. PubMed PMID: 24766878; PubMed Central PMCID: PMC4422376.

Bhushan B, Sheldon S, Wang E, Schroeder JW Jr. Clinical indicators that predict the presence of moderate to severe obstructive sleep apnea after adenotonsillectomy in children. Am J Otolaryngol. 2014 Jul-Aug;35(4):487-95. doi: 10.1016/j.amjoto.2014.02.010. Epub 2014 Feb 26. PubMed PMID: 24746328.

Halawi AM, Simon PE, Lidder AK, Chandra RK. The relationship of the natural sphenoid ostium to the skull base. Laryngoscope. 2015 Jan;125(1):75-9. doi: 10.1002/lary.24393. Epub 2014 Oct 4. PubMed PMID: 24752614.

Lam K, Hirsch AG, Tan BK. The association of premorbid diseases with chronic rhinosinusitis with and without polyps. Curr Opin Otolaryngol Head Neck Surg. 2014 Jun;22(3):231-41. doi: 10.1097/MOO.0000000000000052. Review. PubMed PMID: 24694654; PubMed Central PMCID: PMC4089516.

Mahdavinia M, Carter RG, Ocampo CJ, Stevens W, Kato A, Tan BK, Kern RC, Conley DB, Chandra R, Hulse KE, Suh LA, Norton JE, Peters AT, Grammer LC 3rd, Schwartz LB, Schleimer RP. Basophils are elevated in nasal polyps of patients with chronic rhinosinusitis without aspirin sensitivity. J Allergy Clin Immunol. 2014 Jun;133(6):1759-63. doi: 10.1016/j.jaci.2013.12.1092. Epub 2014 Mar 15. PubMed PMID: 24636088; PubMed Central PMCID: PMC4040310.

Purkey MR, Seeskin Z, Chandra R. Seasonal variation and predictors of epistaxis. Laryngoscope. 2014 Sep;124(9):2028-33. doi: 10.1002/lary.24679. Epub 2014 Apr 29. PubMed PMID: 24633839.

Hulse KE, Chaung K, Seshadri S, Suh L, Norton JE, Carter RG, Kern RC, Conley DB, Chandra RK, Tan BK, Peters AT, Grammer LC 3rd, Harris KE, Torgerson TR, Kato A, Schleimer RP. Suppressor of cytokine signaling 3 expression is diminished in sinonasal tissues from patients with chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2014 Jan;133(1):275-7.e1. doi: 10.1016/j.jaci.2013.08.015. Epub 2013 Sep 29. PubMed PMID: 24084073; PubMed Central PMCID: PMC3897476.

Tan BK, Lu G, Kwasny MJ, Hsueh WD, Shintani-Smith S, Conley DB, Chandra RK, Kern RC, Leung R. Effect of symptom-based risk stratification on the costs of managing patients with chronic rhinosinusitis symptoms. Int Forum Allergy Rhinol. 2013 Nov;3(11):933-40. doi: 10.1002/alr.21208. Epub 2013 Sep 5. PubMed PMID: 24009151.

Smith SS, Evans CT, Tan BK, Chandra RK, Smith SB, Kern RC. National burden of antibiotic use for adult rhinosinusitis. J Allergy Clin Immunol. 2013 Nov;132(5):1230-2. doi: 10.1016/j.jaci.2013.07.009. Epub 2013 Aug 26. PubMed PMID: 23987794; PubMed Central PMCID: PMC3815964.

Lam K, Tan BK, Lavin JM, Meen E, Conley DB. Comparison of nasal sprays and irrigations in the delivery of topical agents to the olfactory mucosa. Laryngoscope. 2013 Dec;123(12):2950-7. doi: 10.1002/lary.24239. Epub 2013 Jun 28. PubMed PMID: 23754343.

Tan BK, Chandra RK, Pollak J, Kato A, Conley DB, Peters AT, Grammer LC, Avila PC, Kern RC, Stewart WF, Schleimer RP, Schwartz BS. Incidence and associated premorbid diagnoses of patients with chronic rhinosinusitis. J Allergy Clin Immunol. 2013 May;131(5):1350-60. doi: 10.1016/j.jaci.2013.02.002. Epub 2013 Mar 28. PubMed PMID: 23541327; PubMed Central PMCID: PMC3788631.

Smith SS, Kern RC, Chandra RK, Tan BK, Evans CT. Variations in antibiotic prescribing of acute rhinosinusitis in United States ambulatory settings. Otolaryngol Head Neck Surg. 2013 May;148(5):852-9. doi: 10.1177/0194599813479768. Epub 2013 Mar 5. PubMed PMID: 23462657.

Takabayashi T, Kato A, Peters AT, Hulse KE, Suh LA, Carter R, Norton J, Grammer LC, Tan BK, Chandra RK, Conley DB, Kern RC, Fujieda S, Schleimer RP. Increased expression of factor XIII-A in patients with chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2013 Sep;132(3):584-592.e4. doi: 10.1016/j.jaci.2013.02.003. Epub 2013 Mar 28. PubMed PMID: 23541322; PubMed Central PMCID: PMC3737402.

Hsueh WD, Conley DB, Kim H, Shintani-Smith S, Chandra RK, Kern RC, Tan BK. Identifying clinical symptoms for improving the symptomatic diagnosis of chronic rhinosinusitis. Int Forum Allergy Rhinol. 2013 Apr;3(4):307-14. doi: 10.1002/alr.21106. Epub 2012 Nov 5. PubMed PMID: 23129294; PubMed Central PMCID: PMC3622790.

Keswani A, Kern RC, Schleimer RP, Kato A. Role of interleukin-32 in chronic rhinosinusitis. Curr Opin Allergy Clin Immunol. 2013 Feb;13(1):13-8. doi: 10.1097/ACI.0b013e32835b35d5. Review. PubMed PMID: 23242112; PubMed Central PMCID: PMC3733344.

Decker JR, Meen EK, Kern RC, Chandra RK. Cost effectiveness of magnetic resonance imaging in the workup of the dysosmia patient. Int Forum Allergy Rhinol. 2013 Jan;3(1):56-61. doi: 10.1002/alr.21066. Epub 2012 Jul 11. PubMed PMID: 22786891.

Carr VM, Robinson AM, Kern RC. Tissue-specific effects of allergic rhinitis in mouse nasal epithelia. Chem Senses. 2012 Sep;37(7):655-68. doi: 10.1093/chemse/bjs048. Epub 2012 Apr 6. PubMed PMID: 22490702.

Wu KN, Tan BK, Howard JD, Conley DB, Gottfried JA. Olfactory input is critical for sustaining odor quality codes in human orbitofrontal cortex. Nat Neurosci. 2012 Sep;15(9):1313-9. doi: 10.1038/nn.3186. Epub 2012 Aug 12. PubMed PMID: 22885850; PubMed Central PMCID: PMC3431433.

Takabayashi T, Kato A, Peters AT, Suh LA, Carter R, Norton J, Grammer LC, Tan BK, Chandra RK, Conley DB, Kern RC, Fujieda S, Schleimer RP. Glandular mast cells with distinct phenotype are highly elevated in chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2012 Aug;130(2):410-20.e5. doi: 10.1016/j.jaci.2012.02.046. Epub 2012 Apr 24. PubMed PMID: 22534535; PubMed Central PMCID: PMC3408832.

Seshadri S, Lin DC, Rosati M, Carter RG, Norton JE, Suh L, Kato A, Chandra RK, Harris KE, Chu HW, Peters AT, Tan BK, Conley DB, Grammer LC, Kern RC, Schleimer RP. Reduced expression of antimicrobial PLUNC proteins in nasal polyp tissues of patients with chronic rhinosinusitis. Allergy. 2012 Jul;67(7):920-8. doi: 10.1111/j.1398-9995.2012.02848.x. PubMed PMID: 22676062; PubMed Central PMCID: PMC3375597.

Leung R, Kern RC, Conley DB, Tan BK, Chandra RK. Establishing a threshold for surgery in recurrent acute rhinosinusitis: a productivity-based analysis. Otolaryngol Head Neck Surg. 2012 May;146(5):829-33. doi: 10.1177/0194599811434709. Epub 2012 Jan 18. PubMed PMID: 22261495.

Cho SH, Hong SJ, Han B, Lee SH, Suh L, Norton J, Lin D, Conley DB, Chandra R, Kern RC, Tan BK, Kato A, Peters A, Grammer LC, Schleimer RP. Age-related differences in the pathogenesis of chronic rhinosinusitis. J Allergy Clin Immunol. 2012 Mar;129(3):858-860.e2. doi: 10.1016/j.jaci.2011.12.002. Epub 2012 Jan 10. PubMed PMID: 22236731; PubMed Central PMCID: PMC3438675.

Peterson S, Poposki JA, Nagarkar DR, Chustz RT, Peters AT, Suh LA, Carter R, Norton J, Harris KE, Grammer LC, Tan BK, Chandra RK, Conley DB, Kern RC, Schleimer RP, Kato A. Increased expression of CC chemokine ligand 18 in patients with chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2012 Jan;129(1):119-27.e1-9. doi: 10.1016/j.jaci.2011.08.021. Epub 2011 Sep 23. PubMed PMID: 21943944; PubMed Central PMCID: PMC3246095.