We have several clinical research studies that are currently enrolling patients.
Short-Term Steroid Therapy in Patients with Chronic Sinusitis (CRS) Without Nasal Polyps
In this study, we would like to determine the most effective route to administer steroids to patients with chronic sinusitis (CRS). There is no conclusive data as to whether oral or sprayed nasal steroids are more effective in providing long-term benefit to patients. We will compare patients who are treated with antibiotics and oral steroids to patients who receive antibiotics and nasally sprayed steroid therapy. Eligible patients will have a diagnosis of CRS and no nasal polyps upon examination. As a subject in this study, you will be randomly assigned (like flipping a coin) to either receive oral steroids or nasally sprayed steroids, in addition to taking a course of antibiotics. We would also like to obtain two research related low-dose CT scans (at no cost) to evaluate your response on treatment. If you are interested in participating in this study, please ask your doctor during your clinic visit.
Chronic Rhinosinusitis (CRS) Registry
The purpose of this registry is to collect clinical information on all consenting chronic rhinosinusitis (CRS) patients seen at the Sinus and Allergy Center. With this information, we will conduct studies to learn more about CRS and determine the most effective ways to treat this disease. The registry will also allow us to identify possible subjects for future studies. We will review the electronic medical records of consenting patients for CRS-relevant medical care and will enter this information into a secure computerized database. Participating in this study may help us better understand CRS, which may lead to improved care and treatment. Consenting patients will complete a 10 minute questionnaire at specific time points. There are additional, optional components such as smell testing and research-related CT scans that will be done at no cost if the patient agrees to these components. If you are interested in participating in this study, please ask your doctor during your clinic appointment.
RESOLVE – Steroid-Releasing S8 Sinus Implant
The goal of this study was to assess the safety and efficacy of the steroid-releasing S8 Sinus Implant in individuals who had functional endoscopic sinus surgery in the past but still experienced nasal and sinus obstruction. The S8 Sinus Implant creates and maintains an opening in the sinus and is intended to provide a physical opening in order to restore ventilation and drainage as well as decrease the feeling of nasal obstruction or congestion. Enrolled subjects who met eligibility criteria were randomly assigned (like flipping a coin) to one of two groups: a treatment group who received the implant and a control group who did not receive the implant.
Aspirin Exacerbated Respiratory Disease (AERD) Study
The purpose of this study is to evaluate the cause of Aspirin Exacerbated Respiratory Disease (AERD) also known as Samter’s Disease. Taking part in this study and participating in the experimental tests required by this study (questionnaires, nasal inspiratory flow, spirometry, nasal endoscopy, nasal culture, smell test, collection of blood, collection of exhaled breath condensate, collection of induced sputum, collection of nasal secretions by lavage or sponges, collection of nasal brushings, collection of saliva, collection of urine, collection and preservation of tissue, and testing of collected tissue )may also help scientists to better understand why people develop AERD, why people with AERD have reactions to medications like aspirin, and why treating AERD patients with high doses of aspirin improve their condition.