We have several clinical research studies that are currently enrolling patients.
Short-Term Steroid Therapy in Patients with Chronic Sinusitis (CRS) Without Nasal Polyps
In this study, we would like to determine the most effective route to administer steroids to patients with chronic sinusitis (CRS). There is no conclusive data as to whether oral or sprayed nasal steroids are more effective in providing long-term benefit to patients. We will compare patients who are treated with antibiotics and oral steroids to patients who receive antibiotics and nasally sprayed steroid therapy. Eligible patients will have a diagnosis of CRS and no nasal polyps upon examination. As a subject in this study, you will be randomly assigned (like flipping a coin) to either receive oral steroids or nasally sprayed steroids, in addition to taking a course of antibiotics. We would also like to obtain two research related low-dose CT scans (at no cost) to evaluate your response on treatment. If you are interested in participating in this study, please ask your doctor during your clinic visit.
Laryngopharyngeal Reflux (LPR) pH Probe
Laryngopharyngeal Reflux (LPR) involves the backflow of stomach contents into the voice box and throat. In this study, we would like to find out whether a device called a pH probe can help physicians predict if a patient will benefit from the current treatment for LPR, called proton pump inhibitor (PPI) medication. In order to do this, the physicians will measure the pH level of patients’ throats before they take PPI medication. Eligible patients will have symptoms that are commonly associated with LPR (e.g hoarseness, throat clearing, postnasal drip sensation, chronic cough or sore throat). If you agree to participate in this study, you will have a small flexible tube (about the size of piece of angel hair pasta) placed in your throat and wear it for 24 hours. This device measures the acidity in your throat continuously. You will not feel the tube when you talk, eat, drink, or swallow and you can follow your daily routine as usual. You will also receive PPI medication which is the standard of care for this condition. You will receive a $100 gift card for participating in this study. If you are interested in participating in this study, please ask your doctor during your clinic visit.
Chronic Rhinosinusitis (CRS) Registry
The purpose of this registry is to collect clinical information on all consenting chronic rhinosinusitis (CRS) patients seen at the Sinus and Allergy Center. With this information, we will conduct studies to learn more about CRS and determine the most effective ways to treat this disease. The registry will also allow us to identify possible subjects for future studies. We will review the electronic medical records of consenting patients for CRS-relevant medical care and will enter this information into a secure computerized database. Participating in this study may help us better understand CRS, which may lead to improved care and treatment. Consenting patients will complete a 10 minute questionnaire at specific time points. There are additional, optional components such as smell testing and research-related CT scans that will be done at no cost if the patient agrees to these components. If you are interested in participating in this study, please ask your doctor during your clinic appointment.
In this study, we would like to determine whether a new device that administers steroid medications in the nose would help improve symptoms of nasal congestion and obstruction in patients with bilateral nasal polyps. Eligible patients will have nasal polyposis seen during nasal endoscopy and at least moderate symptoms of nasal congestion or obstruction for at least 7 days before their screening visit. Ineligible patients are unable to achieve airflow in both sides of the nose, have a history of glaucoma, a cataract, or more than 5 sinonasal surgeries for either nasal polyps or nasal/sinus inflammation, or have had a sinus or nasal surgery within 6 months of the screening visit. As a subject in this study, you will use the device to deliver steroids in your nose for about 6 months. During the first 4 months, the device will either administer a nasal steroid or a placebo (an inactive substance). During the last 2 months, the device will administer a nasal steroid. Your participation will involve 8 visits and you will be paid $25 for each visit. If you are interested in participating in this study, please ask your doctor during your clinic appointment.
MERLOT – Medical Therapy Versus Balloon Sinus Dilation for Patients with Chronic Rhinosinusitis
In this study, we would like to compare health outcomes for patients with chronic rhinosinusitis (CRS) who are treated with continued medical therapy and those who are treated with balloon sinus dilation, a surgical procedure. Both of these options are considered routine medical care. Eligible patients will have radiographically documented CRS and will have tried other treatments to control their symptoms. As a subject in this study, you will discuss the options with your doctor and choose whether you would like to undergo the balloon sinus dilation procedure or continued medical management. Your participation will involve a maximum of 5 visits and you will be followed for one year after enrollment. If you are interested in participating in this study, please ask your doctor during your clinic appointment.