Studies Currently Enrolling Patients

We have several clinical research studies that are currently enrolling patients. If you are already a patient at Northwestern Medical Group and you are interested in participating, please contact Caroline Price at 312-695-0513

If you are not a Northwestern patient but are interested, there are several opportunities to participate in an ongoing clinical study for sinus and allergy research. Find out more at

Clinical Drug Trial in Chronic Rhinosinusitis (E1416)  

This is a Phase 2a, single-center, randomized, placebo-controlled, double-blind study that includes 12 weeks of treatment with experimental drug anti-inflammatory agent or placebo administered orally. All subjects will be ≥18 years, have sinusitis with nasal polyposis persistent severe symptoms despite standard of care treatment, and have failed a course of steroids in the past. The study is 5 months long with a run-in period, treatment period, and a washout period from the study drug. The study includes 7 study visits with procedures such as physical exams, nasal lavages, endoscopic exams and radiographic imaging, symptom questionnaires, and safety blood tests.

Aspirin Exacerbated Respiratory Disease (AERD) Study

The purpose of this study is to evaluate the cause of Aspirin Exacerbated Respiratory Disease (AERD) also known as Samter’s Disease. Taking part in this study and participating in the experimental tests required by this study (questionnaires, nasal inspiratory flow, spirometry, nasal endoscopy, nasal culture, smell test, collection of blood, collection of exhaled breath condensate, collection of induced sputum, collection of nasal secretions by lavage or sponges, collection of nasal brushings, collection of saliva, collection of urine, collection and preservation of tissue, and testing of collected tissue )may also help scientists to better understand why people develop AERD, why people with AERD have reactions to medications like aspirin, and why treating AERD patients with high doses of aspirin improve their condition.

Chronic Rhinosinusitis (CRS) Registry

The purpose of this registry is to collect clinical information on all consenting chronic rhinosinusitis (CRS) patients seen at the Sinus and Allergy Center. With this information, we will conduct studies to learn more about CRS and determine the most effective ways to treat this disease. The registry will also allow us to identify possible subjects for future studies. We will review the electronic medical records of consenting patients for CRS-relevant medical care and will enter this information into a secure computerized database. Participating in this study may help us better understand CRS, which may lead to improved care and treatment. Consenting patients will complete a 10 minute questionnaire at specific time points. There are additional, optional components such as smell testing and research-related CT scans that will be done at no cost if the patient agrees to these components. If you are interested in participating in this study, please ask your doctor during your clinic appointment.