Featured Paper:


A Prospective Analysis Evaluating Tissue Biopsy Location and its Clinical Relevance in Chronic Rhinosinusitis with Nasal Polyps. International Forum of Allergy & Rhinology. 
Ava R. Weibman, BA; Julia He Huang, DDS; Whitney W. Stevens, MD, PhD; Lydia A. Suh, BS; Caroline P.E. Price, BA; Alcina K. Lidder, BA; David B. Conley, MD; Kevin C. Welch, MD; Stephanie Shintani-Smith, MD; Anju T. Peters, MD, MS; Leslie Grammer, MD, Atsushi Kato, PhD, Robert C. Kern, MD1; Robert P. Schleimer, PhD, and Bruce K. Tan, MD, MS. 


Recent Publications:

Min JY, Nayak JV, Hulse KE, Stevens WW, Raju PA, Huang JH, Suh LA, Van Roey GA, Norton JE, Carter RG, Price CPE, Weibman AR, Rashan AR, Ghosn EE, Patel ZM, Homma T, Conley DB, Welch KC, Shintani-Smith S, Peters AT, Grammer LC 3rd, Harris KE, Kato A, Hwang PH, Kern RC, Herzenberg LA, Schleimer RP, Tan BK.Evidence for altered levels of IgD in the nasal airway mucosa of patients with chronic rhinosinusitis.  J Allergy Clin Immunol. 2017 Jun 16. pii: S0091-6749(17)30986-7. doi: 10.1016/j.jaci.2017.05.032. [Epub ahead of print] PMID: 28625807 [PubMed – as supplied by publisher]

Pothoven KL, Schleimer RP. The barrier hypothesis and Oncostatin M: Restoration of epithelial barrier function as a novel therapeutic strategy for the treatment of type 2 inflammatory disease. Tissue Barriers. 2017 Jun 13:e1341367. doi: 10.1080/21688370.2017.1341367. [Epub ahead of print] PMID: 28665760 [PubMed – as supplied by publisher]

Tan BK, Min JY, Hulse KE.Acquired Immunity in Chronic Rhinosinusitis.Curr Allergy Asthma Rep. 2017 Jul;17(7):49. doi: 10.1007/s11882-017-0715-0. Review.PMID: 28623534 [PubMed – in process]

Poposki JA, Klingler AI, Tan BK, Soroosh P, Banie H, Lewis G, Hulse KE, Stevens WW, Peters AT, Grammer LC, Schleimer RP, Welch KC, Smith SS, Conley DB, Raviv JR, Karras JG, Akbari O, Kern RC, Kato A.Group 2 innate lymphoid cells are elevated and activated in chronic rhinosinusitis with nasal polyps.Immun Inflamm Dis. 2017 Apr 19. doi: 10.1002/iid3.161. [Epub ahead of print]PMID: 28474861 [PubMed – as supplied by publisher] Free Article

Hui JW, Ong J, Herdegen JJ, Kim H, Codispoti CD, Kalantari V, Tobin MC, Schleimer RP, Batra PS, LoSavio PS, Mahdavinia M.Risk of obstructive sleep apnea in African American patients with chronic rhinosinusitis.Ann Allergy Asthma Immunol. 2017 Jun;118(6):685-688.e1. doi: 10.1016/j.anai.2017.03.009. Epub 2017 Apr 27.PMID: 28457643 [PubMed – indexed for MEDLINE]

Ghadersohi S, Ference EH, Detwiller K, Kern RC Presentation, workup, and management of penetrating transorbital and transnasal injuries: A case report and systematic review.Am J Rhinol Allergy. 2017 Mar 1;31(2):29-34. doi: 10.2500/ajra.2017.31.4421.PMID: 28452700 [PubMed – in process]

Homma T, Kato A, Sakashita M, Takabayashi T, Norton JE, Suh LA, Carter RG, Harris KE, Peters AT, Grammer LC, Min JY, Shintani-Smith S, Tan BK, Welch K, Conley DB, Kern RC, Schleimer RP.Potential Involvement of the Epidermal Growth Factor Receptor Ligand Epiregulin and Matrix Metalloproteinase-1 in Pathogenesis of Chronic Rhinosinusitis.Am J Respir Cell Mol Biol. 2017 Apr 11. doi: 10.1165/rcmb.2016-0325OC. [Epub ahead of print]PMID: 28398769 [PubMed – as supplied by publisher]

Gouveia CJ, Kern RC, Liu SY, Capasso R.The state of academic sleep surgery: A survey of United States residency and fellowship programs.Laryngoscope. 2017 Mar 27. doi: 10.1002/lary.26572. [Epub ahead of print]PMID: 28349537 [PubMed – as supplied by publisher]

Lavin J, Min JY, Lidder AK, Huang JH, Kato A, Lam K, Meen E, Chmiel JS, Norton J, Suh L, Mahdavinia M, Hulse KE, Conley DB, Chandra RK, Shintani-Smith S, Kern RC, Schleimer RP, Tan BK.Superior turbinate eosinophilia correlates with olfactory deficit in chronic rhinosinusitis patients.Laryngoscope. 2017 Mar 21. doi: 10.1002/lary.26555. [Epub ahead of print] PMID: 28322448 [PubMed – as supplied by publisher]

Stevens WW, Peters AT, Hirsch AG, Nordberg CM, Schwartz BS, Mercer DG, Mahdavinia M, Grammer LC, Hulse KE, Kern RC, Avila P, Schleimer RP.Clinical Characteristics of Patients with Chronic Rhinosinusitis with Nasal Polyps, Asthma, and Aspirin-Exacerbated Respiratory Disease.J Allergy Clin Immunol Pract. 2017 Jul – Aug;5(4):1061-1070.e3. doi: 10.1016/j.jaip.2016.12.027. Epub 2017 Mar 9.PMID: 28286156 [PubMed – in process]

Takahashi T, Kato A, Berdnikovs S, Stevens WW, Suh LA, Norton JE, Carter RG, Harris KE, Peters AT, Hulse KE, Grammer LC, Welch KC, Shintani-Smith S, Tan BK, Conley DB, Kern RC, Bochner BS, Schleimer RP.Microparticles in nasal lavage fluids in chronic rhinosinusitis: Potential biomarkers for diagnosis of aspirin-exacerbated respiratory disease.J Allergy Clin Immunol. 2017 Feb 24. pii: S0091-6749(17)30293-2. doi: 10.1016/j.jaci.2017.01.022. [Epub ahead of print]PMID: 28238741 [PubMed – as supplied by publisher]

Miljkovic D, Ou J, Kirana C, Hulse KE, Hauben E, Psaltis A, Wormald PJ, Vreugde S. Discordant frequencies of tissue-resident and circulating CD180-negative B cells in chronic rhinosinusitis.Int Forum Allergy Rhinol. 2017 Jun;7(6):609-614. doi: 10.1002/alr.21924. Epub 2017 Feb 25.PMID: 28236375 [PubMed – in process]

Lidder AK, Detwiller KY, Price CP, Kern RC, Conley DB, Shintani-Smith S, Welch KC, Chandra RK, Peters AT, Grammer LC 3rd, Man LX, Schleimer RP, Tan BK.Evaluating metrics of responsiveness using patient-reported outcome measures in chronic rhinosinusitis.Int Forum Allergy Rhinol. 2017 Feb;7(2):128-134. doi: 10.1002/alr.21866. Epub 2016 Nov 7.PMID: 28177596 [PubMed – in process]

Pothoven KL, Norton JE, Suh LA, Carter RG, Harris KE, Biyasheva A, Welch K, Shintani-Smith S, Conley DB, Liu MC, Kato A, Avila PC, Hamid Q, Grammer LC 3rd, Peters AT, Kern RC, Tan BK, Schleimer RP. Neutrophils are a major source of the epithelial barrier disrupting cytokine oncostatin M in patients with mucosal airways disease.J Allergy Clin Immunol. 2017 Jun;139(6):1966-1978.e9. doi: 10.1016/j.jaci.2016.10.039. Epub 2016 Dec 18.PMID: 27993536 [PubMed – in process]

Feldman S, Kasjanski R, Poposki J, Hernandez D, Chen JN, Norton JE, Suh L, Carter RG, Stevens WW, Peters AT, Kern RC, Conley DB, Tan BK, Shintani-Smith S, Welch KC, Grammer LC, Harris KE, Kato A, Schleimer RP, Hulse KE.Chronic airway inflammation provides a unique environment for B cell activation and antibody production.Clin Exp Allergy. 2017 Apr;47(4):457-466. doi: 10.1111/cea.12878. Epub 2017 Jan 26. PMID: 28000955 [PubMed – in process]

Van Roey GA, Vanison CC, Wu J, Huang JH, Suh LA, Carter RG, Norton JE, Shintani-Smith S, Conley DB, Welch KC, Peters AT, Grammer LC, Harris KE, Hulse KE, Kato A, Stevens WW, Kern RC, Schleimer RP, Tan BK.Classical complement pathway activation in the nasal tissue of patients with chronic rhinosinusitis.J Allergy Clin Immunol. 2017 Jul;140(1):89-100.e2. doi: 10.1016/j.jaci.2016.11.015. Epub 2016 Dec 12.PMID: 27979430 [PubMed – in process]

Min JY, Ocampo CJ, Stevens WW, Price CP, Thompson CF, Homma T, Huang JH, Norton JE, Suh LA, Pothoven KL, Conley DB, Welch KC, Shintani-Smith S, Peters AT, Grammer LC 3rd, Harris KE, Hulse KE, Kato A, Modyanov NN, Kern RC, Schleimer RP, Tan BK. Proton pump inhibitors decrease eotaxin-3/CCL26 expression in patients with chronic rhinosinusitis with nasal polyps: Possible role of the nongastric H,K-ATPase.J Allergy Clin Immunol. 2017 Jan;139(1):130-141.e11. doi: 10.1016/j.jaci.2016.07.020. Epub 2016 Oct 4. PMID: 27717558 [PubMed – indexed for MEDLINE]

Stevens WW, Schleimer RP.Aspirin-Exacerbated Respiratory Disease as an Endotype of Chronic Rhinosinusitis. Immunol Allergy Clin North Am. 2016 Nov;36(4):669-680. doi: 10.1016/j.iac.2016.06.004. Epub 2016 Sep 13. Review.PMID: 27712762 [PubMed – in process]

Ference EH, Min JY, Chandra RK, Schroeder JW Jr, Ciolino JD, Yang A, Holl J, Shintani Smith S.

Antibiotic Prescribing by Physicians Versus Nurse Practitioners for Pediatric Upper Respiratory Infections.Ann Otol Rhinol Laryngol. 2016 Dec;125(12):982-991. Epub 2016 Oct 5.PMID: 27707916 [PubMed – indexed for MEDLINE]

Hirsch AG, Stewart WF, Sundaresan AS, Young AJ, Kennedy TL, Scott Greene J, Feng W, Tan BK, Schleimer RP, Kern RC, Lidder A, Schwartz BS.Nasal and sinus symptoms and chronic rhinosinusitis in a population-based sample.Allergy. 2017 Feb;72(2):274-281. doi: 10.1111/all.13042. Epub 2016 Sep 19. PMID: 27590749 [PubMed – in process] Free PMC Article

Ghogomu N, Kern R.Chronic rhinosinusitis: the rationale for current treatments.Expert Rev Clin Immunol. 2017 Mar;13(3):259-270. doi: 10.1080/1744666X.2016.1220833. Epub 2016 Aug 24. Review.PMID: 27500700 [PubMed – indexed for MEDLINE]

Levy JM, Rudmik L, Peters AT, Wise SK, Rotenberg BW, Smith TL. Contemporary management of chronic rhinosinusitis with nasal polyposis in aspirin-exacerbated respiratory disease: an evidence-based review with recommendations. Int Forum Allergy Rhinol. 2016 Dec;6(12):1273-1283. doi: 10.1002/alr.21826. Epub 2016 Aug 2. PMID: 27480830 [PubMed – in process]

Stevens WW, Schleimer RP, Kern RC. Chronic Rhinosinusitis with Nasal Polyps. J Allergy Clin Immunol Pract. 2016 Jul-Aug;4(4):565-72. doi: 10.1016/j.jaip.2016.04.012. PMID: 27393770 [PubMed – in process] Free PMC Article

Takahashi S, Mui VJ, Rosenberg SK, Homma K, Cheatham MA, Zheng J. Cadherin 23-C Regulates Microtubule Networks by Modifying CAMSAP3’s Function. Sci Rep. 2016 Jun 28;6:28706. doi: 10.1038/srep28706. PMID: 27349180 [PubMed – in process] Free PMC Article

Lam K, Kern RC, Luong A.Is there a future for biologics in the management of chronic rhinosinusitis?Int Forum Allergy Rhinol. 2016 Sep;6(9):935-42. doi: 10.1002/alr.21780. Epub 2016 Apr 22. Review.PMID: 27103607 [PubMed – in process]

Defining appropriateness criteria for endoscopic sinus surgery during management of uncomplicated adult chronic rhinosinusitis: a RAND/UCLA appropriateness study.Rudmik L, Soler ZM, Hopkins C, Schlosser RJ, Peters A, White AA, Orlandi RR, Fokkens WJ, Douglas R, Smith TL. Rhinology. 2016 Jun;54(2):117-28. doi: 10.4193/Rhin16.023. PMID: 26934470 [PubMed – indexed for MEDLINE]

Daramola OO, Kern RC. An update regarding the treatment of nonallergic rhinitis.Curr Opin Otolaryngol Head Neck Surg. 2016 Feb;24(1):10-4. doi: 10.1097/MOO.0000000000000225. Review. PMID: 26731682 [PubMed – indexed for MEDLINE]

Cramer JD, Kern RC, Tan BK, Peters AT, Evans CT, Smith SS. Laryngoscope. Potential national savings from prescribing guideline-recommended antibiotics for acute rhinosinusitis. 2016 Mar;126(3):579-81. doi: 10.1002/lary.25719. Epub 2015 Oct 28. No abstract available.  PMID: 26509838 [PubMed – in process]

Vieira BL, Hernandez DJ, Qin C, Smith SS, Kim JY, Dutra JC. The impact of resident involvement on otolaryngology surgical outcomes. Laryngoscope. 2016 Mar;126(3):602-7. doi: 10.1002/lary.25046. Epub 2015 Nov 3. PMID: 26526707 [PubMed – in process]

Daramola OO, Kern RC.An update regarding the treatment of nonallergic rhinitis.Curr Opin Otolaryngol Head Neck Surg. 2016 Feb;24(1):10-4. doi: 10.1097/MOO.0000000000000225. PMID: 26731682 [PubMed – in process]

Mahdavinia M, Benhammuda M, Codispoti CD, Tobin MC, Losavio PS, Mehta A, Jeffe JS, Bandi S, Peters AT, Stevens WW, Landay A, Keshavarzian A, Schleimer RP, Batra PS. African American Patients With Chronic Rhinosinusitis Have a Distinct Phenotype of Polyposis Associated With Increased Asthma Hospitalization.. J Allergy Clin Immunol Pract. 2016 Jan 20. pii: S2213-2198(15)00709-6. doi: 10.1016/j.jaip.2015.11.031. [Epub ahead of print] PubMed PMID: 26868728.

Hulse KE. Immune Mechanisms of Chronic Rhinosinusitis.Curr Allergy Asthma Rep. 2016 Jan;16(1):1. doi: 10.1007/s11882-015-0579-0. PubMed PMID: 26677109.

Kern RC. EDITORIAL. Int Forum Allergy Rhinol. 2016 Jan;6(1):5-7. doi: 10.1002/alr.21713. No abstract available. PMID: 26749201 [PubMed – in process]

Thompson CF, Price CP, Huang JH, Min JY, Suh LA, Shintani-Smith S, Conley DB, Schleimer RP, Kern RC, Tan BK. A pilot study of symptom profiles from a polyp vs an eosinophilic-based classification of chronic rhinosinusitis. Thompson Int Forum Allergy Rhinol. 2015 Dec 18. doi: 10.1002/alr.21687. [Epub ahead of print]PMID: 26683389 [PubMed – as supplied by publisher]

Heymann HB, Thompson CF, Lissner GS, Kern RC. Nasoorbital Osteoma Presenting as Valsalva-Induced Orbital Emphysema. Ophthal Plast Reconstr Surg. 2015 Dec 14. [Epub ahead of print] PMID: 26669293 [PubMed – as supplied by publisher]

Rudmik L, Hopkins C, Peters A, Smith TL, Schlosser RJ, Soler ZM. Patient-reported outcome measures for adult chronic rhinosinusitis: A systematic review and quality assessment. J Allergy Clin Immunol. 2015 Dec;136(6):1532-1540.e2. doi: 10.1016/j.jaci.2015.10.012. PMID: 26654198 [PubMed – in process]

Stevens W, Buchheit K, Cahill KN. Aspirin-Exacerbated Diseases: Advances in Asthma with Nasal Polyposis, Urticaria, Angioedema, and Anaphylaxis., and Anaphylaxis. Curr Allergy Asthma Rep. 2015 Dec;15(12):69. doi: 10.1007/s11882-015-0569-2. Review. PubMed PMID: 26475526.

Stevens WW, Lee RJ, Schleimer RP, Cohen NA. Chronic rhinosinusitis pathogenesis. J Allergy Clin Immunol. 2015 Dec;136(6):1442-53. doi: 10.1016/j.jaci.2015.10.009. Review. PMID: 26654193 [PubMed – in process]

Cho SH, Kim DW, Lee SH, Kolliputi N, Hong SJ, Suh L, Norton J, Hulse KE, Seshadri S, Conley DB, Kern RC, Tan BK, Peters A, Grammer LC, Schleimer RP. Age-Related Increased Prevalence of Asthma and Nasal Polyps in Chronic Rhinosinusitis and Its Association with Altered IL-6 Trans-Signaling. Am J Respir Cell Mol Biol. 2015 Nov;53(5):601-6. doi: 10.1165/rcmb.2015-0207RC. PubMed PMID: 26266960.

Gouveia CJ, Qureshi HA, Kern RC, Shintani Smith S. National Institutes of Health Funding for Obstructive Sleep Apnea: An Opportunity for Otolaryngologists. Otolaryngol Head Neck Surg. 2015 Oct;153(4):671-8. doi: 10.1177/0194599815589584. Epub 2015 Jun 17. PubMed PMID: 26084829.

Welch KC. Neurologic Complications and Treatment. Otolaryngol Clin North Am. 2015 Oct;48(5):769-82. doi: 10.1016/j.otc.2015.05.005. Epub 2015 Jul 2. Review. PubMed PMID: 26143103.

Kim DY, Cho SH, Takabayashi T, Schleimer RP. Chronic Rhinosinusitis and the Coagulation System.. Allergy Asthma Immunol Res. 2015 Sep;7(5):421-30. doi: 10.4168/aair.2015.7.5.421. Epub 2015 May 12. Review. PubMed PMID: 26122502; PubMed Central PMCID: PMC4509654.

Li N, Peters AT. Chronic rhinosinusitis management beyond intranasal steroids and saline solution irrigations. Allergy Asthma Proc. 2015 Sep-Oct;36(5):339-43.  doi: 10.2500/aap.2015.36.3866. PubMed PMID: 26314815; PubMed Central PMCID: PMC4548894.

Stevens WW, Ocampo CJ, Berdnikovs S, Sakashita M, Mahdavinia M, Suh L, Takabayashi T, Norton JE, Hulse KE, Conley DB, Chandra RK, Tan BK, Peters AT, Grammer LC 3rd, Kato A, Harris KE, Carter RG, Fujieda S, Kern RC, Schleimer RP. Cytokines in Chronic Rhinosinusitis. Role in Eosinophilia and Aspirin-exacerbated Respiratory Disease. Am J Respir Crit Care Med. 2015 Sep 15;192(6):682-94. doi: 10.1164/rccm.201412-2278OC. PubMed PMID: 26067893; PubMed Central PMCID: PMC4595675.

Abdala-Valencia H, Bryce PJ, Schleimer RP, Wechsler JB, Loffredo LF, Cook-Mills JM, Hsu CL, Berdnikovs S. Tetraspanin CD151 Is a Negative Regulator of FcεRI-Mediated Mast Cell Activation.J Immunol. 2015 Aug 15;195(4):1377-87. doi: 10.4049/ jimmunol.1302874.Epub 2015 Jul 1. PubMed PMID: 26136426.

Hirsch AG, Yan XS, Sundaresan AS, Tan BK, Schleimer RP, Kern RC, Kennedy TL, Greene JS, Schwartz BS. Five-year risk of incident disease following a diagnosis of chronic rhinosinusitis. Allergy. 2015 Aug 31. doi: 10.1111/all.12759. [Epub ahead of print] PubMed PMID: 26332371.

Bhushan B, Homma T, Norton JE, Sha Q, Siebert J, Gupta DS, Schroeder JW Jr, Schleimer RP. Suppression of epithelial signal transducer and activator of transcription 1 activation by extracts of Aspergillus fumigatus. Am J Respir Cell Mol Biol. 2015 Jul;53(1):87-95. doi: 10.1165/rcmb.2014-0333OC. PubMed PMID: 25474274; PubMed Central PMCID: PMC4566112.

Chandra RK, Kern RC, Cutler JL, Welch KC, Russell PT. REMODEL larger cohort with long-term outcomes and meta-analysis of standalone balloon dilation studies. Laryngoscope. 2015 Jul 30. doi: 10.1002/lary.25507. [Epub ahead of print] PubMed PMID: 26228589.

Seshadri S, Lu X, Purkey MR, Homma T, Choi AW, Carter R, Suh L, Norton J, Harris KE, Conley DB, Kato A, Avila PC, Czarnocka B, Kopp PA, Peters AT, Grammer LC, Chandra RK, Tan BK, Liu Z, Kern RC, Schleimer RP. Increased expression of the epithelial anion transporter pendrin/SLC26A4 in nasal polyps of patients with chronic rhinosinusitis. J Allergy Clin Immunol. 2015 Jul 1. pie: S0091-6749(15)00730-7. doi: 10.1016/j.jaci.2015.05.024. [Epub ahead of print] PubMed PMID: 26143180.

Sundaresan AS, Hirsch AG, Storm M, Tan BK, Kennedy TL, Greene JS, Kern RC, Schwartz BS. Occupational and environmental risk factors for chronic rhinosinusitis: a systematic review. Int Forum Allergy Rhinol. 2015 Jun 16. doi: 10.1002/alr.21573. [Epub ahead of print] PubMed PMID: 26077513.

Ference EH, Smith SS, Conley D, Chandra RK. Surgical anatomy and variations of the infraorbital nerve. Laryngoscope. 2015 Jun;125(6):1296-300. doi: 10.1002/lary.25089. Epub 2015 Jan 13. PubMed PMID: 25992806.

Lobo BC, Ting JY, Tan BK. Cost efficient workup and management of patients with chronic rhinosinusitis – challenges and unmet needs. Curr Otorhinolaryngol Rep. 2015 Jun;3(2):94-100. PubMed PMID: 26029489; PubMed Central PMCID: PMC4443922.

Homma T, Kato A, Sakashita M, Norton JE, Suh LA, Carter RG, Schleimer RP. Involvement of Toll-like receptor 2 and epidermal growth factor receptor signaling in epithelial expression of airway remodeling factors. Am J Respir Cell Mol Biol. 2015 Apr;52(4):471-81. doi: 10.1165/rcmb.2014-0240OC. PubMed PMID: 25180535; PubMed Central PMCID: PMC4491124.

Kato A. Immunopathology of chronic rhinosinusitis.Allergol Int. 2015 Apr;64(2):121-30. doi: 10.1016/j.alit.2014.12.006. Epub 2015 Feb 9. Review. PubMed PMID: 25838086; PubMed Central PMCID: PMC4675657.

Kern RC. Historical classics: Editorial. Laryngoscope. 2015 Apr;125(4):773. doi: 10.1002/lary.25216. Epub 2015 Mar 14. PubMed PMID: 25773495.

Qureshi H, Ference E, Novis S, Pritchett CV, Smith SS, Schroeder JW. Trends in the management of pediatric peritonsillar abscess infections in the U.S., 2000-2009. Int J Pediatr Otorhinolaryngol. 2015 Apr;79(4):527-31. doi: 10.1016/j.ijporl.2015.01.021. Epub 2015 Jan 28. PubMed PMID: 25708703.

Qureshi HA, Ference EH, Tan BK, Chandra RK, Kern RC, Smith SS. National trends in retropharyngeal abscess among adult inpatients with peritonsillar abscess. Otolaryngol Head Neck Surg. 2015 Apr;152(4):661-6. doi: 10.1177/0194599814568286. Epub 2015 Jan 20. PubMed PMID: 25605696.

Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, Brook I, Ashok Kumar K, Kramper M, Orlandi RR, Palmer JN, Patel ZM, Peters A, Walsh SA, Corrigan MD. Clinical practice guideline (update): adult sinusitis. Otolaryngol Head Neck Surg. 2015 Apr;152(2 Suppl):S1-S39. doi: 10.1177/0194599815572097. PubMed PMID: 25832968.

Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, Brook I, Kumar KA, Kramper M, Orlandi RR, Palmer JN, Patel ZM, Peters A, Walsh SA, Corrigan MD. Clinical practice guideline (update): Adult Sinusitis Executive Summary.. Otolaryngol Head  Neck Surg. 2015 Apr;152(4):598-609. doi: 10.1177/0194599815574247. PubMed PMID: 25833927.

Kashani S, Carr TF, Grammer LC, Schleimer RP, Hulse KE, Kato A, Kern RC, Conley DB, Chandra RK, Tan BK, Peters AT. Clinical characteristics of adults with chronic rhinosinusitis and specific antibody deficiency. J Allergy Clin Immunol Pract. 2015 Mar-Apr;3(2):236-42. doi: 10.1016/j.jaip.2014.09.022. Epub 2014 Nov 25. PubMed PMID: 25609325; PubMed Central PMCID: PMC4391952.

Kashani S, Carr TF, Grammer LC, Schleimer RP, Hulse KE, Kato A, Kern RC, Conley DB, Chandra RK, Tan BK, Peters AT. Clinical characteristics of adults with chronic rhinosinusitis and specific antibody deficiency. J Allergy Clin Immunol Pract. 2015 Mar-Apr;3(2):236-42. doi: 10.1016/j.jaip.2014.09.022. Epub 2014 Nov 25. PubMed PMID: 25609325; PubMed Central PMCID: PMC4391952.

Schoepfer AM, Panczak R, Zwahlen M, Kuehni CE, Coslovsky M, Maurer E, Haas NA, Alexander JA, Dellon ES, Gonsalves N, Hirano I, Leung J, Bussmann C, Collins MH, Newbury RO, De Petris G, Smyrk TC, Woosley JT, Yan P, Yang GY, Romero Y, Katzka DA, Furuta GT, Gupta SK, Aceves SS, Chehade M, Blanchard C, Straumann A, Safroneeva E; International EEsAI Study Group. How do gastroenterologists assess overall activity of eosinophilic esophagitis in adult patients? Am J Gastroenterol. 2015 Mar;110(3):402-14. doi: 10.1038/ajg.2015.32. Epub 2015 Mar 3. PubMed PMID: 25732414.

Stevens WW, Peters AT, Suh L, Norton JE, Kern RC, Conley DB, Chandra RK, Tan BK, Grammer LC, Harris KE, Carter RG, Kato A, Urbanek M, Schleimer RP, Hulse KE. A retrospective, cross-sectional study reveals that women with CRSwNP have more severe disease than men. Immun Inflamm Dis. 2015 Mar;3(1):14-22. doi: 10.1002/iid3.46. Epub 2015 Feb 12. PubMed PMID: 25866636; PubMed Central PMCID: PMC4386911.

Stevens WW, Peters AT. Immunodeficiency in chronic sinusitis: recognition and treatment. Am J Rhinol Allergy. 2015 Mar-Apr;29(2):115-8. doi: 10.2500/ajra.2015.29.4144. Review. PubMed PMID: 25785751.

Hulse KE, Stevens WW, Tan BK, Schleimer RP. Pathogenesis of nasal polyposis. Clin Exp Allergy. 2015 Feb;45(2):328-46. doi: 10.1111/cea.12472. Review. PubMed PMID: 25482020; PubMed Central PMCID: PMC4422388.

Lam K, Conley DB, Liu K, Kern RC, Tan BK, Richter CP. Effect of ionic compositions in nasal irrigations on human olfactory thresholds. Laryngoscope. 2015 Feb;125(2):E50-6. doi: 10.1002/lary.24941. Epub 2014 Sep 30. PubMed PMID: 25267347.

Mahdavinia M, Suh LA, Carter RG, Stevens WW, Norton JE, Kato A, Tan BK, Kern RC, Conley DB, Chandra R, Lavin J, Peters AT, Grammer LC 3rd, Schleimer RP. Increased noneosinophilic nasal polyps in chronic rhinosinusitis in US second-generation Asians suggest genetic regulation of eosinophilia. J Allergy Clin Immunol. 2015 Feb;135(2):576-9. doi: 10.1016/j.jaci.2014.08.031. EPub 2014 Oct 11. PubMed PMID: 25312761; PubMed Central PMCID: PMC4323954.

Min JY, Tan BK. Risk factors for chronic rhinosinusitis. Curr Opin Allergy Clin Immunol. 2015 Feb;15(1):1-13. doi: 10.1097/ACI.0000000000000128. Review. PubMed PMID: 25479315; PubMed Central PMCID: PMC4368058.

Poposki JA, Peterson S, Welch K, Schleimer RP, Hulse KE, Peters AT, Norton J, Suh LA, Carter R, Harris KE, Grammer LC, Tan BK, Chandra RK, Conley DB, Kern RC,  Kato A. Elevated presence of myeloid dendritic cells in nasal polyps of patients with chronic rhinosinusitis. Clin Exp Allergy. 2015 Feb;45(2):384-93. doi: 10.1111/cea.12471. PubMed PMID: 25469646; PubMed Central PMCID: PMC4467201.

Thompson CF, Conley DB. What is the optimal maxillary antrostomy size during sinus surgery? Curr Opin Otolaryngol Head Neck Surg. 2015 Feb;23(1):34-8. doi: 10.1097/MOO.0000000000000128. Review. PubMed PMID: 25502601.

Thompson CF, Kern RC, Conley DB. Olfaction in Endoscopic Sinus and Skull Base Surgery. Otolaryngol Clin North Am. 2015 Oct;48(5):795-804. dos: 10.1016/j.otc.2015.05.007. Epub 2015 Jun 24. Review. PubMed PMID: 26117298

Ference EH, Graber M, Conley D, Chandra RK, Tan BK, Evans C, Pynnonen M, Smith SS. Operative utilization of balloon versus traditional endoscopic sinus surgery. Laryngoscope. 2015 Jan;125(1):49-56. doi: 10.1002/lary.24901. Epub 2014 Sep 2. PubMed PMID: 25180840; PubMed Central PMCID: PMC4349682.

Halawi AM, Simon PE, Lidder AK, Chandra RK. The relationship of the natural sphenoid ostium to the skull base. Laryngoscope. 2015 Jan;125(1):75-9. doi: 10.1002/lary.24393. Epub 2014 Oct 4. PubMed PMID: 24752614.

Bachert C, Pawankar R, Zhang L, Bunnag C, Fokkens WJ, Hamilos DL, Jirapongsananuruk O, Kern R, Meltzer EO, Mullol J, Naclerio R, Pilan R, Rhee CS, Suzaki H, Voegels R, Blaiss M. ICON: chronic rhinosinusitis. World Allergy Organ J. 2014 Oct 27;7(1):25. doi: 10.1186/1939-4551-7-25. eCollection 2014. PubMed PMID: 25379119; PubMed Central PMCID: PMC4213581.

Purkey MR, Seeskin Z, Chandra R. Seasonal variation and predictors of epistaxis. Laryngoscope. 2014 Sep;124(9):2028-33. doi: 10.1002/lary.24679. Epub 2014 Apr 29. PubMed PMID: 24633839.

Bhushan B, Sheldon S, Wang E, Schroeder JW Jr. Clinical indicators that predict the presence of moderate to severe obstructive sleep apnea after adenotonsillectomy in children. Am J Otolaryngol. 2014 Jul-Aug;35(4):487-95. doi: 10.1016/j.amjoto.2014.02.010. Epub 2014 Feb 26. PubMed PMID: 24746328.

Lam K, Hirsch AG, Tan BK. The association of premorbid diseases with chronic rhinosinusitis with and without polyps. Curr Opin Otolaryngol Head Neck Surg. 2014 Jun;22(3):231-41. doi: 10.1097/MOO.0000000000000052. Review. PubMed PMID: 24694654; PubMed Central PMCID: PMC4089516.

Mahdavinia M, Carter RG, Ocampo CJ, Stevens W, Kato A, Tan BK, Kern RC,Conley DB, Chandra R, Hulse KE, Suh LA, Norton JE, Peters AT, Grammer LC 3rd, Schwartz LB, Schleimer RP. Basophils are elevated in nasal polyps of patients with chronic rhinosinusitis without aspirin sensitivity.J Allergy Clin Immunol. 2014 Jun;133(6):1759-63. doi: 10.1016/j.jaci.2013.12.1092. Epub 2014 Mar 15. PubMed PMID: 24636088; PubMed Central PMCID: PMC4040310.

Catalli A, Karpov V, Erdos LE, Tancowny BP, Schleimer RP, Kulka M. Stimulus-selective regulation of human mast cell gene expression, degranulation and leukotriene production by fluticasone and salmeterol. PLoS One. 2014 May 12;9(5):e96891. doi: 10.1371/journal.pone.0096891. eCollection 2014. PubMed PMID:24819142; PubMed Central PMCID: PMC4018391.

Stevens WW, Schleimer RP, Chandra RK, Peters AT. Biology of nasal polyposis..  J Allergy Clin Immunol. 2014 May;133(5):1503, 1503.e1-4. doi: 10.1016/j.jaci.2014.03.022. PubMed PMID: 24766878; PubMed Central PMCID: PMC4422376.

Hulse KE, Chaung K, Seshadri S, Suh L, Norton JE, Carter RG, Kern RC, Conley DB, Chandra RK, Tan BK, Peters AT, Grammer LC 3rd, Harris KE, Torgerson TR, Kato A, Schleimer RP. Suppressor of cytokine signaling 3 expression is diminished in sinonasal tissues from patients with chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2014 Jan;133(1):275-7.e1. doi: 10.1016/j.jaci.2013.08.015. Epub 2013 Sep 29. PubMed PMID: 24084073; PubMed Central PMCID: PMC3897476.

Hulse KE, Chaung K, Seshadri S, Suh L, Norton JE, Carter RG, Kern RC, Conley DB, Chandra RK, Tan BK, Peters AT, Grammer LC 3rd, Harris KE, Torgerson TR, Kato  A, Schleimer RP. Suppressor of cytokine signaling 3 expression is diminished in sinonasal tissues from patients with chronic rhinosinusitis with nasal polyps. J  Allergy Clin Immunol. 2014 Jan;133(1):275-7.e1. doi: 10.1016/j.jaci.2013.08.015. Epub 2013 Sep 29. PubMed PMID: 24084073; PubMed Central PMCID: PMC3897476.

Lam K, Tan BK, Lavin JM, Meen E, Conley DB. Comparison of nasal sprays and irrigations in the delivery of topical agents to the olfactory mucosa. Laryngoscope. 2013 Dec;123(12):2950-7. doi: 10.1002/lary.24239. Epub 2013 Jun 28. PubMed PMID: 23754343.

Tan BK, Lu G, Kwasny MJ, Hsueh WD, Shintani-Smith S, Conley DB, Chandra RK, Kern RC, Leung R. Effect of symptom-based risk stratification on the costs of managing patients with chronic rhinosinusitis symptoms. Int Forum Allergy Rhinol. 2013 Nov;3(11):933-40. doi: 10.1002/alr.21208. Epub 2013 Sep 5. PubMed PMID: 24009151.

Takabayashi T, Kato A, Peters AT, Hulse KE, Suh LA, Carter R, Norton J, Grammer LC, Tan BK, Chandra RK, Conley DB, Kern RC, Fujieda S, Schleimer RP. Increased expression of factor XIII-A in patients with chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2013 Sep;132(3):584-592.e4. doi: 10.1016/j.jaci.2013.02.003. Epub 2013 Mar 28. PubMed PMID: 23541322; PubMed Central PMCID: PMC3737402.

Smith SS, Evans CT, Tan BK, Chandra RK, Smith SB, Kern RC. National burden of antibiotic use for adult rhinosinusitis. J Allergy Clin Immunol. 2013 Nov;132(5):1230-2. doi: 10.1016/j.jaci.2013.07.009. Epub 2013 Aug 26. PubMed PMID: 23987794; PubMed Central PMCID: PMC3815964.

Smith SS, Kern RC, Chandra RK, Tan BK, Evans CT. Variations in antibiotic prescribing of acute rhinosinusitis in United States ambulatory settings. Otolaryngol Head Neck Surg. 2013 May;148(5):852-9. doi: 10.1177/0194599813479768. Epub 2013 Mar 5. PubMed PMID: 23462657.

Tan BK, Chandra RK, Pollak J, Kato A, Conley DB, Peters AT, Grammer LC, Avila PC, Kern RC, Stewart WF, Schleimer RP, Schwartz BS. Incidence and associated premorbid diagnoses of patients with chronic rhinosinusitis. J Allergy Clin Immunol. 2013 May;131(5):1350-60. doi: 10.1016/j.jaci.2013.02.002. Epub 2013 Mar 28. PubMed PMID: 23541327; PubMed Central PMCID: PMC3788631.

Hsueh WD, Conley DB, Kim H, Shintani-Smith S, Chandra RK, Kern RC, Tan BK. Identifying clinical symptoms for improving the symptomatic diagnosis of chronic rhinosinusitis. Int Forum Allergy Rhinol. 2013 Apr;3(4):307-14. doi: 10.1002/alr.21106. Epub 2012 Nov 5. PubMed PMID: 23129294; PubMed Central PMCID: PMC3622790.

Keswani A, Kern RC, Schleimer RP, Kato A. Role of interleukin-32 in chronic rhinosinusitis. Curr Opin Allergy Clin Immunol. 2013 Feb;13(1):13-8. doi: 10.1097/ACI.0b013e32835b35d5. Review. PubMed PMID: 23242112; PubMed Central PMCID: PMC3733344.

Decker JR, Meen EK, Kern RC, Chandra RK. Cost effectiveness of magnetic resonance imaging in the workup of the dysosmia patient. Int Forum Allergy Rhinol. 2013 Jan;3(1):56-61. doi: 10.1002/alr.21066. Epub 2012 Jul 11. PubMed PMID: 22786891.

Carr VM, Robinson AM, Kern RC. Tissue-specific effects of allergic rhinitis in mouse nasal epithelia. Chem Senses. 2012 Sep;37(7):655-68. doi: 10.1093/chemse/bjs048. Epub 2012 Apr 6. PubMed PMID: 22490702.

Wu KN, Tan BK, Howard JD, Conley DB, Gottfried JA. Olfactory input is critical for sustaining odor quality codes in human orbitofrontal cortex. Nat Neurosci. 2012 Sep;15(9):1313-9. doi: 10.1038/nn.3186. Epub 2012 Aug 12. PubMed PMID: 22885850; PubMed Central PMCID: PMC3431433.

Takabayashi T, Kato A, Peters AT, Suh LA, Carter R, Norton J, Grammer LC, Tan BK, Chandra RK, Conley DB, Kern RC, Fujieda S, Schleimer RP. Glandular mast cells with distinct phenotype are highly elevated in chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2012 Aug;130(2):410-20.e5. doi: 10.1016/j.jaci.2012.02.046. Epub 2012 Apr 24. PubMed PMID: 22534535; PubMed Central PMCID: PMC3408832.

Seshadri S, Lin DC, Rosati M, Carter RG, Norton JE, Suh L, Kato A, Chandra RK, Harris KE, Chu HW, Peters AT, Tan BK, Conley DB, Grammer LC, Kern RC, Schleimer RP. Reduced expression of antimicrobial PLUNC proteins in nasal polyp tissues of patients with chronic rhinosinusitis. Allergy. 2012 Jul;67(7):920-8. doi: 10.1111/j.1398-9995.2012.02848.x. PubMed PMID: 22676062; PubMed Central PMCID: PMC3375597.

Leung R, Kern RC, Conley DB, Tan BK, Chandra RK. Establishing a threshold for surgery in recurrent acute rhinosinusitis: a productivity-based analysis. Otolaryngol Head Neck Surg. 2012 May;146(5):829-33. doi: 10.1177/0194599811434709. Epub 2012 Jan 18. PubMed PMID: 22261495.

Cho SH, Hong SJ, Han B, Lee SH, Suh L, Norton J, Lin D, Conley DB, Chandra R, Kern RC, Tan BK, Kato A, Peters A, Grammer LC, Schleimer RP. Age-related differences in the pathogenesis of chronic rhinosinusitis. J Allergy Clin Immunol. 2012 Mar;129(3):858-860.e2. doi: 10.1016/j.jaci.2011.12.002. Epub 2012 Jan 10. PubMed PMID: 22236731; PubMed Central PMCID: PMC3438675.

Peterson S, Poposki JA, Nagarkar DR, Chustz RT, Peters AT, Suh LA, Carter R, Norton J, Harris KE, Grammer LC, Tan BK, Chandra RK, Conley DB, Kern RC, Schleimer RP, Kato A. Increased expression of CC chemokine ligand 18 in patients with chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2012 Jan;129(1):119-27.e1-9. doi: 10.1016/j.jaci.2011.08.021. Epub 2011 Sep 23. PubMed PMID: 21943944; PubMed Central PMCID: PMC3246095.

Ference EH, Schroeder JW Jr, Qureshi H, Conley D, Chandra RK, Tan BK, Shintani Smith S. Current utilization of balloon dilation versus endoscopic techniques in pediatric sinus surgery. Otolaryngol Head Neck Surg. 2014 Nov;151(5):852-60. doi: 10.1177/0194599814545442. Epub 2014 Aug 4. Erratum in: Otolaryngol Head Neck Surg. 2015 Aug;153(2):310-1. PubMed PMID: 25091194.

Daramola OO, Lidder AK, Ramli R, Chandra RK, Shintani-Smith S, Conley DB, Kern RC, Tan BK. Patient knowledge and perception of computed tomography scan in the management of chronic rhinosinusitis symptoms. Laryngoscope. 2015 Apr;125(4):791-5. doi: 10.1002/lary.24992. Epub 2014 Oct 24. PubMed PMID: 25346013; PubMed Central PMCID: PMC4376556.

Ference EH, Stubbs V, Lidder AK, Chandra RK, Conley D, Avila PC, Hirsch AG, Min JY, Shintani Smith S, Kern RC, Tan BK. Measurement and comparison of health utility assessments in chronic rhinosinusitis. Int Forum Allergy Rhinol. 2015 Oct;5(10):929-36. doi: 10.1002/alr.21556. Epub 2015 Jun 16. PubMed PMID: 26077390; PubMed Central PMCID: PMC4607564.

Ference EH, Tan BK, Hulse KE, Chandra RK, Smith SB, Kern RC, Conley DB, Smith SS. Commentary on gender differences in prevalence, treatment, and quality of life of patients with chronic rhinosinusitis. Allergy Rhinol (Providence). 2015 Jan;6(2):82-8. doi: 10.2500/ar.2015.6.0120. PubMed PMID: 26302727; PubMed Central PMCID: PMC4541639.

Gawron AJ, Feinglass J, Pandolfino JE, Tan BK, Bove MJ, Shintani-Smith S. Brand name and generic proton pump inhibitor prescriptions in the United States: insights from the national ambulatory medical care survey (2006-2010). Gastroenterol Res Pract. 2015;2015:689531. doi: 10.1155/2015/689531. Pub 2015 Feb 5. PubMed PMID: 25733976; PubMed Central PMCID: PMC4334865.

Lam K, Schleimer R, Kern RC. The Etiology and Pathogenesis of Chronic Rhinosinusitis: a Review of Current Hypotheses. Curr Allergy Asthma Rep. 2015 Jul;15(7):41. doi: 10.1007/s11882-015-0540-2. Review. PubMed PMID: 26143392.

Mahdavinia M, Hsu J, Norton JE, Carter RG, Simon P, Siebert J, Cheatem L, Suh LA, Peters AT, Grammer LC 3rd, Kato A, Tan BK, Conley DB, Avila PC, Kern RC, Pinto JM, Schleimer RP. Association of common filaggrin null mutations with atopy but not chronic rhinosinusitis. Ann Allergy Asthma Immunol. 2015 May;114(5):420-1. doi: 10.1016/j.anai.2015.01.019. Epub 2015 Mar 4. PubMed PMID: 25747786; PubMed Central PMCID: PMC4426019.

Pothoven KL, Norton JE, Hulse KE, Suh LA, Carter RG, Rocci E, Harris KE, Shintani-Smith S, Conley DB, Chandra RK, Liu MC, Kato A, Gonsalves N, Grammer LC 3rd, Peters AT, Kern RC, Bryce PJ, Tan BK, Schleimer RP. Oncostatin M promotes mucosal epithelial barrier dysfunction, and its expression is increased in patients with eosinophilic mucosal disease. J Allergy Clin Immunol. 2015 Sep;136(3):737-746.e4. doi: 10.1016/j.jaci.2015.01.043. Epub 2015 Apr 1. PubMed PMID: 25840724; PubMed Central PMCID: PMC4562861.